32 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology of Tumor Lysis ... Syndrome (TLS) ... Tumor Cell Lysis ... Hypocalcemia • Hyperkalemia ... #TumorLysis #Syndrome
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... 6L/day) • For hyperkalemia ... wandering_er #Tumor #Lysis ... #Syndrome #TLS
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Syndrome Leukostasis ... organ damage • Treatment ... Low calcium • Treatment ... hydration - Hyperkalemia ... treatment (no calcium
Hypercalcemia - EKG Findings
Causes of Hypercalcemia 
• Malignancy 
• Milk-alkali syndrome 
• Vitamin D toxicity 
•
Hypercalcemia - ... Findings Causes of Hypercalcemia ... • Milk-alkali syndrome ... Thiazide diuretics #Hypercalcemia ... #EKG #ECG #Electrocardiogram
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... and Treatment of ... hydroxide • Hyperkalemia ... #TumorLysis #Syndrome
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Causes of HyperKalemia ... Rhabdomyolysis • Tumor lysis ... syndrome • Metabolic ... MCW_Nephrology #HyperKalemia
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... Suspicion for Hyperkalemia ... release due to cell lysis ... reaction - Tumor lysis ... syndrome - Rhabdomyolysis
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Cancer Related • Hypercalcemia ... malignancies Treatment ... Capillary leak syndrome ... Interleukin-2) • Tumor lysis ... syndrome • Proximal
Causes of Hypermagnesemia
Increased magnesium load
 - Magnesium-containing laxatives, antacids, or enemas
 - Treatment of pre-edampsia/eclampsia (mothers
or enemas - Treatment ... untreated) - Tumor lysis ... hypocalciuric hypercalcemia
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... hyperuricemia, #hyperkalemia