361 results
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase ... - Differential Diagnosis ... disturbance (obstructed liver ... Highest • Bone • Liver ... #Differential #Diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
- Differential Diagnosis ... with alkaline phosphatase ... increase in alkaline phosphate ... Injury Differential Diagnosis ... #Differential #Diagnosis
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... ALT) / (alkaline phosphatase ... + ULN alkaline phosphatase ... Transaminitis #diagnosis
Liver Function Tests (LFTs)
 - Aspartate aminotransferase (AST) 
 - Alanine aminotransferase (ALT) 
 - Alkaline
Liver Function Tests ... - Alkaline phosphatase ... Prothrombin #Liver ... LFTs #Laboratory #Diagnosis
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Low Alkaline Phosphatase ... synthesized in: liver ... Most cases diagnosed ... Difficulty walking Diagnosis ... Hyophosphatasia #hepatology #diagnosis
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... Transaminase >> Alkaline Phosphatase ... Pattern - Alkaline Phosphatase ... Transaminitis #diagnosis
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
- Differential Diagnosis ... heparin Acute Phosphate ... intake, Phosphate ... Increased Renal Phosphate ... #Differential #Diagnosis
Hypophosphatemia and Hypoxia - Pathophysiology

↓ Phosphate leads to ↓ red cell 2,3-DPG and a  reduction
Pathophysiology ↓ Phosphate ... ↓ Phosphate diverts ... ↓ Phosphate does ... ↓ Phosphate leads ... the contractile properties
Hypophosphatemia - Measurement of urine phosphate excretion - Differential Diagnosis Algorithm
 • GI loss
 • Redistribution
Measurement of urine phosphate ... - Differential Diagnosis ... urine #urinary #phosphate ... #Differential #Diagnosis
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... ALT, Alkaline Phosphatase ... In liver, 80% of ... Alkaline phosphatase ... Pathophysiology #Diagnosis