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diagnosis differential causes oncology secondary dermatology systemic workup generalized leukemia pruritus syndromes approach blood bonemarrow classification cll disorders failure fatigue
Aplastic Anemia and Bone Marrow Failure Syndromes with Pancytopenia Fanconi Anemia Acquired Aplastic Anemia Dyskeratosis Congenita & Telemore Biology
Aplastic Anemia ... with Pancytopenia ... Acquired Aplastic ... lauraebrown #Pancytopenia ... #Hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Neutropenia with Pancytopenia ... Differential Diagnosis Algorithm ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... deficiencies #Pancytopenia
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Differential Diagnosis Algorithm ... Polycythemia Vera • Chronic ... : • Acute or Chronic ... Iron deficiency anemia ... Differential #Diagnosis #Algorithm
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... HLH syndrome 5. ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... HLH syndrome 5 ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... hemorrhage) • Chronic ... Myelodysplastic syndrome ... Myelofibrosis (MF) • Chronic ... Diagnosis #Causes #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... bone marrow + pancytopenia ... • Peripheral Pancytopenia ... #hematology #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... hemolysis, deficiency anemia ... Kawasaki, Nephrotic syndrome ... • Infections: Chronic ... Differential #Diagnosis #Algorithm
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... RBCs on Smear • Chronic ... Deficiency • Aplastic ... of Chronic Disease ... #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Differential Diagnosis Algorithm ... • Marrow Aplasia ... RA, SLE, PRV, Chronic ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
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