1130 results
Schizophrenia: Pathogenesis and Symptoms
Increased dopaminergic transmission in mesolimbic projection
-> Dopaminergic neurons here project into the limbic
Pathogenesis and Symptoms ... in mesolimbic projection ... cause the Positive Symptoms ... in mesocortical projection ... decision-making, language production
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
(SLE) Signs / Symptoms ... Decreased tear production ... Decreased saliva production ... Decreased sebum production ... Diagnosis #Signs #Symptoms
Lung Abscess
Microbiology:
 • Polymicrobial 
 • Anaerobes (most common) 
Clinical: 
 • Indolent symptoms that evolve
• Indolent symptoms ... cough, sputum production
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Estrogen) • Inhibit production ... Osteoclasts • Inhibit production ... pathophysiology #signs #symptoms
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
hepatocellular aerobic ATP production ... increased lactate production ... also includes symptoms
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
to excess TSH production ... Signs/Symptoms:
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
enzymes, joint fluid production ... diagnosis #signs #symptoms
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
resulting from the production ... varied clinical symptoms ... There are several symptoms
Venn Diagram - Does this patient have pneumonia?
Diagnosis is generally based on three lines of evidence:
- Pulmonary symptoms ... cough, sputum production
Allergic Bronchopulmonary Aspergillosis (ABPA)
WHAT IS IT?
Hypersensitivity response to Aspergillus fumigatus in the airways
 • Primarily affects
increased mucus production ... ARE THE CLINICAL SYMPTOMS ... Increased cough or production