1385 results
Gout: Pathogenesis and Clinical Findings
 - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders
 -
turnover: hemolysis, psoriasis ... easily leaks into joints ... in a peripheral joint ... Neutrophils enter joint ... Hyperuricemia #Pathophysiology
Psoriatic Arthritis: Pathogenesis and Clinical findings

In tendons and connective tissues:
 • Enthesitis  - Pain/tenderness over
Psoriatic Arthritis ... soft tissue and joints ... In skin: • Psoriatic ... Arthritis of DIP joints ... PsoriaticArthritis #pathophysiology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Joint Disorders ... Lumbar Spine and SI Joints ... Molecular Mimicry” • Psoriatic ... skin disorder psoriasis ... @AmyChung #Joint
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Approach to Joint ... 3) Number of Joints ... Number of Joints ... ): • Septic joint ... Chronic = RA, SLE, psoriatic
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
Pathogenesis and Joint ... poly-articular joint ... Joint involvement ... space decr joint ... RheumatoidArthritis #RA #pathophysiology
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
Inflammatory Joint ... Oligoarticular (1-4 joints ... ) • Gout • Psoriatic ... POLYARTICULAR (>4 joints ... • Asymmetric (Psoriatic
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint ... Plaques • Psoriasis ... arthritis • Psoriatic ... #dermatology #joint
Rheumatoid arthritis (RA): X-ray features
 • Soft tissue swelling (best seen by comparing left & right
together) • Joint ... closer to the joints ... ) • Joint Subluxations ... (Joint deformities ... Radiology #Clinical #Pathophysiology
Reactive Arthritis
 • Inflammation of joints (commonly large joints)
    - Asymmetric Oligoarthritis: Joint
Inflammation of joints ... commonly large joints ... Oligoarthritis: Joint ... pain in a few joints ... ReactiveArthritis #pathophysiology
Arthritis of the Hand - Arthritis Patterns

Osteoarthritis:
• Osteoarthritis of the hand usually involves the DIP and
the DIP and PIP joints ... the PIP and MCP joints ... but not the DIP joints ... neck deformity Psoriatic ... Sarcoidosis • Psoriatic