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SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
nonerosive inflammatory arthritis ... , psoriasis vulgaris ... disease. ... SAPHO #Syndrome #Rheumatology ... #diagnosis #management
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
infection • Lyme disease ... Plaques • Psoriasis ... migrans • Lyme disease ... • Psoriatic arthritis ... differential #diagnosis #rheumatology
Seronegative Inflammatory Arthritis - Differential Diagnosis
 • Seronegative Rheumatoid Arthritis 
 • Infectious Arthritis: Viral, Bacterial,
Systemic Rheumatic Disease ... Sclerosis, Sjogren's Disease ... Sarcoidosis, Still's Disease ... Ankylosing Spondylitis, Psoriatic ... #Diagnosis #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Onycholysis - Psoriatic ... • Pitting - Psoriatic ... Scleroderma Thickened skin ... of digits • Psoriatic ... differential #diagnosis #rheumatology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Molecular Mimicry” • Psoriatic ... arthritis - with ... the skin disorder ... psoriasis (7-30% ... Inflammatory Bowel Disease
Rheumatoid Arthritis - ACR 2021 Guidelines
 - Low Disease Activity
 - Moderate to High Disease Activity
Rheumatoid Arthritis ... Guidelines - Low Disease ... Moderate to High Disease ... ACR2021 #Guidelines #management ... #treatment #rheumatology
Causes of Severe Aortic Regurgitation - Differential Diagnosis
Acute:
 • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute
Fever, Whipple Disease ... , Crohn Disease ... , Psoriatic Arthritis ... , IgG4 Disease, ... Cogan's Disease
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Fever, Arthralgia/arthritis ... , Skin rash ± odynophagia ... #diagnosis #management ... #treatment #rheumatology
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
) • Gout • Psoriatic ... • Rheumatoid Arthritis ... • Asymmetric (Psoriatic ... Arthritis) Migratory ... ) • Psoriatic
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
response to local skin ... retinal damage) • Skin ... test (this is a skin ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology