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liver transaminitis algorithm function interpretation tests arterial chemistry classification embolism gastroenterology hepatitis hepatocellular idiosyncratic induced laboratory management pathophysiology rheumatology rvalue
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Liver Injury (DILI ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
) - Differential ... (>1000): • DILI ... (Drug-induced liver ... injury) • Ischemic ... Diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential ... Differential Diagnosis ... valproate, azoles), Drugs ... Diagnosis #hepatology ... Transaminitis #LFTs
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Function Tests (LFTs ... hepatocellular injury ... impaired uptake (drugs ... Interpretation #diagnosis ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis ... #LFTs #RValue #
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Diagnosis Framework ... • Intravenous Drug ... Pregnancy • Drugs ... Vasculitis • Injury ... pathophysiology #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... Diagnosis Framework ... diminished, or tender pulses ... Tests: • CBC • LFT ... #diagnosis #rheumatology
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