11 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Differential Diagnosis Algorithm ... Abnormal peripheral smear ... • Extrinsic RBC ... • Intrinsic RBC
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
AIHA • Anemia ... : macrocytic > normocytic ... ↑ LDH • Anti-RBC ... C3d • Blood smear ... #management #treatment
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Differential Diagnosis Algorithm ... Polychromatic Macrocytes ... Bleed • Hemolysis ... Polychromatic Macrocytes ... Microangiopathic Hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Peripheral blood smear ... Hypochromic & microcytic ... RBCs, DAT (-) →
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Algorithm Mean ... 95 (or 100) is macrocytic ... acute blood loss, hemolysis ... #Macrocytic
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach ... , CKD • Hemolytic ... Spherocytosis, G6PD, PK, HbC ... Infections Macrocytic ... #MCV #Algorithm
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Differential Diagnosis Algorithm ... Normal Blood Smear ... • Drugs Oval Macrocytes ... Neutrophils - Low RBC ... RBCs in Rouleaux
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
Algorithm for the ... evaluation of macrocytic ... (RBC = red blood ... ordering a peripheral smear ... Hemorrhage or hemolysis
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
anorexia, ARDS ​• RBC ... lysis → severe hemolytic ... anemia, jaundice ... phase: Peripheral smear ... TREATMENT: ​• Acute
Borrelia recurrentis on Peripheral Blood Smear
23M Somali refugee recently arrived w/severe abd pain, confusion and fever
Peripheral Blood Smear ... Hgb 12.5, WBC 14 ... Treatment is tetracycline ... initiation of treatment ... BloodSmear #microscopy #pathology