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Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
/ Normochromic RBCs ... TIBC, Hypochromic RBCs ... Decreased RBC ... Disorder • RBC ... Diagnosis #Algorithm #Causes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Macrocytes, Normal RBCs ... Spherocytes, RBC ... ) - Abnormal RBCs ... Diagnosis #Algorithm #Causes
Several artifacts can cause significant and potentially misleading alterations to measured RBC parameters: 1. Old samples
artifacts can cause ... alterations to measured RBC ... RBCs to swell, ... RBCs to shrink, ... a falsely low RBC
FAT RBC Mnemonic for Causes of Macrocytic Anemia (MCV > 100) F - Folate (Fetus) and B12 Deficiency
FAT RBC Mnemonic ... for Causes of Macrocytic ... synthesis for RBC ... Larger, immature RBCs ... FATRBC #Mnemonic #Causes
Hematuria Workup and Diagnosis Algorithm • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Urinalysis >3 RBCs ... (proteinuria, RBC ... casts, dysmorphic ... RBCs)? ... Nephrology if cause
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... == Decreased RBC ... Glucose Content • RBC ... Reduction == Increase RBC ... Dilutional Effect • RBC
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
Hematuria: 3 or more RBC ... hematuria: - RBC ... - Dysmorphic RBC ... disease Renal Causes ... Mass Ureteral Causes
Plasmodium Falciparum Blood Smear. Key features suggesting Plasmodium falciparum: - extreme parasitemia - normocytic RBCs (vivax, ovale prefer big
parasitemia - normocytic RBCs ... multiples per RBC ... P. falciparum causes ... human malaria cases
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... - Fe/TlBC, MCV/RBC ... Deficiency (Eg Causes ... TIBC Normal - MCV/RBC ... inclusions in RBC
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Neutrophils - Low RBC ... Pernicious Anemia RBCs ... Diagnosis #Algorithm #Causes
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