13 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Hypocomplementemia - CHAMPS ... S - Systemic Lupus ... Hypocomplementemia #Low #Complement ... #CHAMPS #Mnemonic
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... 90% - Low complement ... Workup: - ANA ... 80% - Low complement ... sle #comparison #table
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
Criteria - Systemic Lupus ... ACUTE CUTANEOUS LUPUS ... CHRONIC CUTANEOUS LUPUS ... IMMUNOLOGIC CRITERIA - ANA ... anticoagulant - Low complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Workup: - ANA ... 80% - Low complement ... Lupusreference #SLE #lupus
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic lupus ... Farr assay) and lupus ... searched for when ANA ... #rheumatology #table ... #ANA
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus ... (SLE): ANA (anti-nuclear ... glycoprotein I (ß2GP), Lupus ... #associations #table
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... antigens, leading to complement ... they activate complement ... glomerulonephritis, Systemic lupus ... types #allergy #table
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
laboratory findings (ANA ... anti-Smith Ab, low complements ... Serositis Labs: • ANA ... RNP antibodies, Complement ... antibodies • (-) ANA
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... , and systemic lupus ... Diagnosis #Reactions #Table
Giant AAA on POCUS

Elderly pt with abd/back pain. Stable. Has pulsatile mass on exam spans 12
Giant AAA on POCUS ... Stable. ... Too big for a AAA ... answer (of course)-POCUS ... #Giant #POCUS #