14 results
Treatment of Non-hepatitis C virus Cryoglobulinemia Vasculitis - French Vasculitis Study Group

MONOCLONAL CRYOGLOBULINEMIA (TYPE 1) 
IgM
Study Group MONOCLONAL ... (TYPE 1) IgM ... monoclonal component ... (TYPES II AND III ... Vasculitis #Management #Rheumatology
Cryoglobulinemia Classification Types

Type 1: Monoclonal IgM (rarely IgG/lgA)
 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Cryoglobulinemia ... Classification ... Monoclonal IgM ... 2: Monoclonal IgM ... #Types #hematology
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
characterized into 3 types ... arterioles) MONOCLONAL ... (type l) : Vascular ... (types II and Ill ... Vasculitis #Diagnosis #Rheumatology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
POEMS, AL amyloid, Cryoglobulinemia ... Schnitzler syndrome • Cryoglobulinemia ... immunotactoid GN, Type ... Differential #Diagnosis #hematology ... #oncology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... Cryoglobulins: - Single monoclonal ... - Composed of monoclonal ... #classification ... #rheumatology #
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... categorized into 3 sub-types ... level (non-IgM type ... #Significance #hematology ... #diagnosis #oncology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... Immunotactoid GN & Cryoglobulinemic ... WM: Vasculitis (Cryoglobulinemic ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
chains - Screen for monoclonal ... for detection of monoclonal ... factor - Screen for cryoglobulinemias ... (types 2 and 3) ... glomerular #testing #workup
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
chains - Screen for monoclonal ... for detection of monoclonal ... factor - Screen for cryoglobulinemias ... (types 2 and 3) ... glomerular #disease #workup
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
translocation • Types ... : Classification ... on: - Cell type ... NonHodgkins #comparison #oncology ... #differential #hematology