RadialHead em pcc differential causes ams hepatology anemia liver hemolysis workup

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Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production:
• Increased Reticulocytosis/polychromasia
• Erythroid

Algorithm and Causes ... #Hemolytic #Anemia ... #Algorithm #Differential ... #Causes #Workup ... #Hematology #Diagnosis

Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
-

Causes of Extravascular ... - Differential ... Cold AIHA • PCH ... anemia • ... #Hematology

Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80

Causes of Anemia ... Volume (MCV) - Differential ... • Bleeding • Hemolysis ... Renal Disease, Liver ... #Hematology

Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
• Enzyme deficiencies ex. G6PD, pyruvate kinase
• Hemoglobinopathies

Differential Diagnosis ... for Hemolytic Anemia ... : • Liver disease ... HUS, DIC, HELLP, AS ... #Anemia #Differential

Hemolysis - Differential Diagnosis Framework

1) Environment
- Fragmentation
- MAHA: TTP, HUS, DIC, HELLP

Hemolysis - Differential ... Grafts, Valves, AS ... Drug-associated, PCH ... Defects, Drugs, Liver ... Defects: Sickle cell anemia

Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury:
• Hepatic vein:

- Differential ... Algorithm Vascular Causes ... Bilirubin: RBC (hemolysis ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology

Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
- Prior platelet count, family

Platelet Disorders - Differential ... Diagnosis and Workup ... : INR/PT, aPTT(liver ... changes), high MCV anemia ... #Workup #hematology

TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A

Haptoglobin - Low as ... anemia Indirect ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology

Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
• Female:Male 9:1
• Common European descent
• Age:

intralobular bile ducts causes ... or higher • Liver ... bile ducts Differential ... cholangitis #diagnosis #workup ... #hepatology

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

• Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... Disorders Such As ... #anemia #hematology

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