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ana antibodies antinuclear autoantibodies classification differential erythematosus management myositis symptoms systemic vasculitis workup activation algorithm antiphospholipid apls associations autoimmune behcet
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... Others: SRP, Mi-2, ... Autoantibodies #Rheumatology ... #table
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
is clinically suspected ... overlap syndromes ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
TIF1y, NXP2, Mi-2, ... Syndrome: Jo-1, ... Antibodies #MSAs #clinical ... #diagnosis #rheumatology ... #table
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
, holster sign, ... anti-synthetase syndrome ... Can also see mechanics ... weakness after 2 ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
microscopy and serial ... likely it will be clinically ... ), Sjogren's Syndrome ... ANA #patterns #rheumatology ... #diagnosis #differential
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
SJIA], systemic lupus ... erythematosus [SLE ... Increased soluble IL-2 ... #Diagnosis #Management ... #Hematology #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Damage Through 2 ... : • Clinical triad ... Labs/Diagnosis: ... (e.g. systemic lupus ... classification #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
(Clinical Dx). ... Oral aphthae : SLE ... • Arthritis: SLE ... #signs #symptoms ... #rheumatology #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Orange or Hep C Clinical ... Physical Exam/Signs ... • Richter’s Syndrome ... workup #oncology #hematology
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