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diagnosis hematology bruising abnormal algorithm bleeding pt anemia arterial clots extravascular hemolysis hemolytic hemorrhage hemostasis management obgyn obstetrics pediatrics peds
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Disseminated intravascular ... coagulation (DIC ... #Prolonged #Causes ... #diagnosis #differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... anemia): - Disseminated ... intravascular coagulation ... (DIC) - HELLP ... #Causes #differential
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Coagulation (DIC ... Thrombocytopenia • Prolonged ... #Disseminated # ... Intravascular #Coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... hemorrhage • Disseminated ... intravascularcoagulation (DIC ... #Prolonged #Causes ... #hematology #coagulation
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... . prolonged/induced ... HELLP syndrome • Disseminated ... intravascular coagulation ... (DIC) • Anti-coagulation
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... endocarditis) - Disseminated ... intravascular coagulation ... MAHA: TTP, HUS, DIC
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... / Bruising - Differential ... Rare • Drugs (e.g ... Deficiency • Disseminated ... Intravascular Coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... the PT remains prolonged ... liver failure, disseminated ... intravascular coagulation ... discern these causes
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... purpura - DIC ... (disseminated intravascular ... coagulation) ... pediatrics #diagnosis #differential
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