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diagnosis differential bruising coagulation abnormal algorithm anemia aptt bleeding hemolytic pt arterial clots hemolysis hemorrhage hemostasis maha management microangiopathic microscopy
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - Intravascular ... Causes Intravascular ... intravascular coagulation ... (DIC) - HELLP ... hemoglobinuria (PNH) Extravascular
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... endocarditis) - Disseminated ... intravascular coagulation ... MAHA: TTP, HUS, DIC
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... Disseminated intravascular ... coagulation (DIC ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Thrombocytopenia • Prolonged ... #Disseminated # ... Intravascular #Coagulation ... treatment #management #hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... conditions such as disseminated ... intravascular coagulation ... count, D-dimer, egg ... hemolytic #anemia #Hematology
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... . prolonged/induced ... HELLP syndrome • Disseminated ... intravascular coagulation ... (DIC) • Anti-coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Rare • Drugs (e.g ... Deficiency • Disseminated ... Intravascular Coagulation ... #Hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Diagnosis for a Prolonged ... Causes include : ... hemorrhage • Disseminated ... intravascularcoagulation (DIC ... #differential #hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... purpura - DIC ... (disseminated intravascular ... infiltration (e.g ... Purpura #Bruising #Causes
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
the PT remains prolonged ... liver failure, disseminated ... intravascular coagulation ... discern these causes ... Differential #Diagnosis #Hematology
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