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diagnosis differential coagulation bruising abnormal algorithm anemia aptt bleeding hemolytic arterial clots hemolysis hemorrhage hemostasis isth laboratory maha management microangiopathic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
vs Extravascular ... Causes Intravascular ... anemia): - Disseminated ... (DIC) - HELLP ... #Extravascular
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... Disseminated intravascular ... coagulation (DIC ... #differential #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation ... (DIC) Platelet ... using INR use PT ... Intravascular #Coagulation ... Scoring #diagnosis #hematology
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... endocarditis) - Disseminated ... intravascular coagulation ... MAHA: TTP, HUS, DIC
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Thrombocytopenia • Prolonged ... PT/PTT • Low ... Intravascular #Coagulation ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and aPTT If ... the PT and the ... hemorrhage • Disseminated ... intravascularcoagulation (DIC ... #differential #hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... conditions such as disseminated ... intravascular coagulation ... count, D-dimer, egg ... hemolytic #anemia #Hematology
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... . prolonged/induced ... HELLP syndrome • Disseminated ... intravascular coagulation ... (DIC) • Anti-coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Rare • Drugs (e.g ... Deficiency • Disseminated ... Intravascular Coagulation ... #Hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
prolonged after ... liver failure, disseminated ... intravascular coagulation ... discern these causes ... Differential #Diagnosis #Hematology
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