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diagnosis causes algorithm management rheumatology thrombocytopenia activation anemia bruising conditions extrarticular extravascular hemolysis hemolytic hemorrhage intravascular joint macrophage mas neutropenia
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Syndrome - Diagnosis ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... vonWillebrand #Syndrome ... #hematology #differential
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Toxic Damage (e.g ... Displacement (e.g ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS • DIC ... Foreign Surface (e.g
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation (DIC ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... (usually IgG) (e.g ... #diagnosis #hematology
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Post-Partum Hemorrhage - Differential ... TTP) • HELLP syndrome ... intravascular coagulation (DIC ... Hemorrhage #PPH #Differential ... Causes #Obstetrics #OBGyn
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Haemolytic uraemic syndrome ... Kasabach—Merritt syndrome ... Wiskott—Aldrich syndrome ... Bernard—Soulier syndrome ... infiltration (e.g
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Periodic fever syndromes ... underlying disease (eg ... • Infection (eg ... hypersensitivity syndromes
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
GI - Felty syndrome ... • Felty's syndrome ... Shrinking lung syndrome ... disease, Vasculitis (e.g ... SLE, Behçet's syndrome
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
hypertension and/or drug treatment ... Constitutional disorders, eg ... neutropenia, Kostmann syndrome ... Chediak-Higashi syndrome ... diagnosis #causes #hematology
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