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diagnosis differential symptoms management complications gh hypocalcemia secondary 21hydroxylasedeficiency 21ohd algorithm bulimianervosa calcium cushings diabetes diabeticketoacidosis dka encephalopathy excess feedbackloop
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... Pseudohyperparathyroidism, Renal ... calcium)-alkali syndrome ... #Causes #differential ... calcium #high #endocrinology
Causes of Hypercalcemia Parathyroid hormone–dependent Primary hyperparathyroidism Familial hypocalciuric hypercalcemia Lithium-associated Tertiary hyperparathyroidism Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Causes of Hypercalcemia ... hypocalciuric hypercalcemia ... thyrotoxicosis, adrenal ... #Causes #Differential ... #Diagnosis #Endocrinology
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 Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... - Soft tissue expansion ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... Carpal Tunnel Syndrome ... fraction • HTN #GrowthHormone ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Causes of Hypercalcemia ... , adrenal, prostate ... • Milk-alkali syndrome ... #Hypercalcemia ... #Causes #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... 21-OHD in the adrenal ... Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology
Hypophosphatemia - Differential Diagnosis Algorithm Transcellular Shift • Recovery From DKA • Refeeding Syndrome • Acute Respiratory
• Refeeding Syndrome ... Increased Excretion - Renal ... • Acute Volume Expansion ... Diagnosis #Algorithm #endocrinology ... #causes
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... hyperphosphatemia, hypercalcemia ... , and possibly renal ... patients) and/or hypercalcuria ... Diagnosis #Management #Signs
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
hypertension and signs ... bruit or signs ... Vasculitis • Endocrinologic ... Hyperthyroidism, Hypercalcemia ... White-coat syndrome
Adrenal Insufficiency - Diagnosis and Management Summary Primary Adrenal Insufficiency: Most Common Cause in the US: Autoimmune Adrenalitis Other
: Most Common Cause ... Adrenalitis Other causes ... Hyperkalemia is ... hypophysitis, Sheehan's syndrome ... Diagnosis #Management #Endocrinology
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