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diagnosis differential causes nephrology hypokalemia hyperkalemia low alkalosis antiarrhythmics cardiology metabolic pathophysiology pharmacology anemia chloride clinicopathology diabetes dm2 dmii evaluation
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Phase I - Initial Repolarization ... Vaughan Williams Classification ... CLASS 3 - Potassium ... Block K+ channels (primarily ... #Pharmacology #Classification
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
Vaughan Williams Classification ... prolong AV node repolarization ... CLASS 3 - Potassium ... Block K+ channels (primarily ... #Pharmacology #Classification
Hypokalemia - Differential Diagnosis Poor Intake - Starvation - Anorexia GI Losses - Vomiting / NG
Ureterosigmoidostomy Urinary ... tubular acidosis (Types ... and 2, but not type ... Diagnosis #Low #Potassium ... #Table #Classification
Hyperkalemia: Diagnostic algorithm Decreased renal potassium excretion • Acute renal failure • Chronic renal failure • Drugs Increased
Hyperkalemia: Diagnostic algorithm ... Normal, Renin High ... : • Primary hypoaldosteronism ... hypoplasia Aldosterone high ... Hyperkalemia #Diagnosis #algorithm
Hypokalemia - Differential Diagnosis Algorithm Extra-renal Losses: • Normal Acid-Base: Low intake • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... Syndrome • HTN, High ... secreting tumor, Primary ... Differential #Diagnosis #Algorithm ... #causes #potassium
Causes of Metabolic Alkalosis - Differential Diagnosis Chloride depletion syndromes • Gastrointestinal losses -
chloridorrhea - High-volume ... syndromes • Primary ... dehydrogenase type ... syndrome • Severe potassium ... depletion (serum potassium
Causes of Hypokalemia - Differential Diagnosis Algorithm Defining the cause of hypokalemia starts by measuring urinary K
Differential Diagnosis Algorithm ... either secondary or primary ... tubular acidosis (type ... Gitelman's syndrome • Primary ... #potassium
The Diagnostic Approach to Hyperkalemia Drugs - Amiloride - Spironolactone - Triamterene - Trimethoprim - Pentamidine -
obstruction _ pHA type ... I, type II - ... transplant - SLE High ... Renin - Primary ... #Hyperkalemia #Algorithm
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation Algorithm ... treated with IV potassium ... losses: • High ... ↑ Aldosterone: Primary ... #differential #potassium
Hypokalemia Differential Diagnosis Algorithm Hypertensive: • High Al, Low R - Primary aldosteronism • High Al, High
Differential Diagnosis Algorithm ... Al, Low R - Primary ... Differential #Diagnosis #Algorithm ... #nephrology #causes ... #low #potassium
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