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Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... increased bone Ca2+ resorption ... increased GI Ca2+ absorption ... Hypercalcemia #Causes
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Miscellaneous - Bone Resorption ... - Calcium Reabsorption ... Diagnosis #Algorithm #causes
Causes of Hypocalcemia - Differential Diagnosis Decreased calcium absorption • Vitamin D deficiency -
Causes of Hypocalcemia ... excretion/reduced bone resorption ... resistance to bone resorption ... resistance to bone resorption ... Differential #Diagnosis #Causes
Polyuria - Differential Diagnosis Solute Diuresis • Na intake/saline • Glucosuria: Hyperglycemia, SGLT-2 inhibitors • Urea: Exogenous
breakdown, TPN, Resolution ... Differential #Diagnosis #Causes
Drug-Induced Thrombocytopenia The diagnosis of drug-induced thrombocytopenia can be made only by demonstrating resolution of thrombocytopenia once
demonstrating resolution ... #Medications #Causes
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 Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Abnormal Osteoclasts cause ... turnover -> Incr bone resorption ... • Incr Bone resorption ... Skull expansion causes ... middle ear bones causes
Pancreatic Duct Stones on Ultrasound Dilated pancreatic duct with calculi in pancreatic duct. Helpful tip- If pancreatic
Ductal obstruction caused ... these stones is a cause ... Stone resolution
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 Hypercalcemia of Malignancy - Pathophysiology PTH-mediated • Parathyroid cancer • Ectopic production: Small cell lung cancer, ovarian
intestinal calcium absorption ... and stimulates resorption ... Stimulate calcium reabsorption ... kidney, Stimulates resorption
Paget's Disease of Bone • Characterized by an ↑ rate of bone turnover with both excessive
both excessive resorption ... • Caused by (
Phenobarbital monotherapy algorithm for alcohol withdrawal ** EDIT - SEE UPDATED ALGORITHM HERE: https://www.grepmed.com/images/4060/phenobarbital-monotherapy-withdrawal-management-algorithm-protocol-pulmcrit -Phenobarbital monotherapy has numerous advantages
achieve clinical resolution ... Alternative causes
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