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diagnosis management differential symptoms systemic hematology ana antinuclear disease erythematosus lupus sle autoantibodies blood dermatology patterns product reactions treatment vasculitis
Cutaneous and Systemic Findings in Dermatomyositis Cutaneous Findings: - Heliotrope sign and edema - Nail-fold changes -
Systemic Findings in Dermatomyositis ... Interstitial lung disease ... tract - Cardiac disease ... #Dermatomyositis ... #Diagnosis #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... Polymyositis and dermatomyositis ... polyangiitis without renal ... Antineutrophil #antibodies ... #diagnosis #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... connective tissue disease ... , Polymyositis/Dermatomyositis ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... Polymyositis / Dermatomyositis ... (TTG) - Celiac disease ... diagnosis #table #rheumatology ... #antibodies
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... , Polymyositis/Dermatomyositis ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... severity of the disease ... #rheumatology #
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
SLE-Related Auto-Antibodies ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... autoantibodies #signs ... #differential #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune disease ... skin thickening Signs ... : scleroderma renal ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Primary Adrenal Insufficiency Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Insufficiency Addison's Disease ... Lymphoma Metastatic Disease ... Lung cancer • Renal ... 21-Hydroxylase Antibodies ... 21-hydroxylase antibodies
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
, dermatomyositis ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies
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