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differential oncology rheumatology syndrome algorithm criticalcare hemophagocytic hlh lymphohistiocytosis summary acne anemia aplastic apml atopic atopy cardiology cd4 cell cheatsheet
Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Diagnosis of TTP: • Rare and severe, ADAMTS13 deficiency • Autoimmune
Purpura (TTP) Diagnosis ... admission to the ICU ... Thrombocytopenic #Purpura #management ... #treatment #rheumatology ... #hematology
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
- NEJM 1999 - ICU ... unnecessary and cause ... /vmoitra) #EBM ... Transfusion #Thresholds #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
biologics (CMV +++, EBV ... Drugs, Unknown cause ... Treatment: • ... of emergency, ICU ... #management #treatment
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
CD4 Lymphopenia (ICL ... CRITERIA FOR ICL ... EBV. CMV. ... #Lymphopenia #ICL ... #diagnosis #hematology
COVID-19 - A Seattle Intensivist's One-Page Cheat-Sheet on COVID-19 v2.7 Updated March 26 2020 (v2.7) incorporating newer
COVID19 in the ICU ... data on mortality rate ... 31 • First US case ... #Management #Summary ... : Marino's The ICU
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... opacities • Diagnosis ... Renal Failure Treatment ... organ dysfuxtion, ICU ... #management #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... start and stop dates ... non-essential drug/HDS treatments ... for alternative causes ... HBV, HCV, HEV, EBV
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Toxic injury to BM ... and petechiae Causes ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... organ damage • Treatment ... proliferation rate ... Syndrome #TLS #diagnosis ... #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
+ Bleeding Treatment ... Treat primary cause ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
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