214 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... Anti-Smith, Anti-Ro ... Polymerase Ill • ANCA ... Vasculitis: P-ANCA ... perinuclear), C-ANCA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... Anti-Ro/SSA ... 80-90%) > MPO - ANCA ... Jcortesizaguirr #ANA
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and ... Disease Associations ANA ... SLE Anti-SSA (Ro ... Graves' disease c-ANCA ... granulomatosis p-ANCA
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis) - ANCA-negative ... testing: anti-ANCA ... , anti-GBM ab, ANA ... , biopsy By Tess
Effects of Strokes by Location - Anterior vs Posterior Localization

Anterior Circulation 
 - MCA 
 -
- MCA - ACA ... circulation - ASA ... - PICA - AICA ... GrepMed Recommended Text
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Associated - ANCA ... Granulomas - ANCA ... 80-90% have PR3-ANCA ... retinopathy Lab Tests ... LFT • ESR • ANA
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Antinuclear antibody (ANA ... with SLE have ANAs ... thus, a negative ANA ... ACE level, CXR, ANCA ... multiple myeloma) • ANA
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Antinuclear (ANA ... Initial screening test ... activity Anti-Ro ... Ann Marie Kumfer
Knee Examination
Right Knee - Examination maneuvers include the Lachman (ACL), anterior drawer (ACL), Lateral pivot shift,
meniscal integrity) and ... meniscal integrity) tests ... McMurray #Drawer #Test ... #msk
Flexor Tenosynovitis (FTS)

The clinical diagnosis of FTS is made using Kanavel’s Signs:
 - Fusiform swelling.
 -
slight flexion at rest ... Infographic by Anna ... Criteria #Sign #Hand #MSK