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clinical ultrasound diagnosis echocardiogram cardiology rheumatology abdominal differential management pulmonary ana antinuclear hydronephrosis labeled plax renal sbo table workup a4c
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Anti-Smith, Anti-Ro ... Syndrome: Anti-Ro ... Polymerase Ill • ANCA ... Vasculitis: P-ANCA ... perinuclear), C-ANCA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... Anti-Ro/SSA ... 80-90%) > MPO - ANCA ... MPO: 75-80% - ANCA ... Antinuclear #Antibody #ANCA
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Disease Associations ANA ... SLE Anti-SSA (Ro ... Graves' disease c-ANCA ... granulomatosis p-ANCA
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis) - ANCA-negative ... Disease-specific testing ... : anti-ANCA ab, ... anti-GBM ab, ANA
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... ANA - Screen for ... ANCA - Screen for ... ANCA-related vasculitis ... #glomerular #testing
ASE Guidelines for Noninvasive Vascular Testing • Carotid Arteries • Renal Arteries • Lower Extremities #Noninvasive #Vascular
Noninvasive Vascular Testing ... Noninvasive #Vascular #Testing ... #POCUS
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Antinuclear (ANA ... activity Anti-Ro
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
laboratory findings (ANA ... lesions • Anti-Ro ... Diagnosis: • ANCA-associated ... • Anti-Smith, Ro ... + (+) anti-Ro/SSA
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... glomerular disease. 8) ANA ... disorders. 9) ANCA ... - Screen for ANCA-related ... diagnosis #initial #testing
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
- CCP antibody testing ... ACE level, CXR, ANCA ... myositis • Thyroid testing ... and C serology testing ... workup #diagnosis #testing
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