802 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Anti-Smith, Anti-Ro ... Syndrome: Anti-Ro ... • Scleroderma (Systemic
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... activity Anti-Ro ... • MCTD (SLE/systemic ... @AnnKumfer #Systemic
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
antibodies) • Systemic ... drug-induced SLE) • Systemic ... Anti-Ro/SSA
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lesions • Anti-Ro ... Neuropsychiatric systemic ... • Anti-Smith, Ro ... ANA + (+) anti-Ro
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic ... 40% Target: SS-A/Ro ... autoantibodies #Systemic
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Antibodies: Anti-Ro ... Antibodies: • Anti-Ro ... Central nervous system ... Peripheral nervous system ... Cytopenia: 2% Systemic
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
central nervous system ... Peripheral Nervous System ... Serology: - Anti-Ro
The parasympathetic and sympathetic systems - Activation and inhibition pathways by organ system

#Sympathetic #Parasympathetic #Systems #Pathways
and sympathetic systems ... pathways by organ system ... Parasympathetic #Systems
Commonly Used Clinical Grading Systems
 • Edema Grading Scale
 • Hepatic Encephalopathy Grading (West Haven Criteria)
Clinical Grading Systems ... Criteria) • Systolic ... DharSaty #Grading #Systems
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Systemic Sclerosis ... Scleroderma) Multi-system ... Limited cutaneous systemic ... knees • Diffuse systemic ... and/or trunk • Systemic