1947 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Anti-Smith, Anti-Ro ... Antiphospholipid Antibody Syndrome ... LAC) • Sjogren Syndrome ... : Anti-Ro (SSA), ... • Scleroderma (Systemic
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... activity Anti-Ro ... block • Sjogren syndrome ... • MCTD (SLE/systemic ... polymyositis overlap syndrome
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
antibodies) • Systemic ... drug-induced SLE) • Systemic ... cases • Sjögren syndrome ... Anti-Ro/SSA
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Antibodies: Anti-Ro ... Antibodies: • Anti-Ro ... Central nervous system ... Peripheral nervous system ... Cytopenia: 2% Systemic
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lesions • Anti-Ro ... Neuropsychiatric systemic ... • Anti-Smith, Ro ... ANA + (+) anti-Ro
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic ... 40% Target: SS-A/Ro ... SLE-SSc-AlM overlap syndromes ... autoantibodies #Systemic
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... central nervous system ... Peripheral Nervous System ... Paraneoplastic syndrome ... Serology: - Anti-Ro
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
BEE Syndromes - ... central nervous system ... causes: • Susac syndrome ... • Sjögren syndrome ... • Systemic lupus
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... Nephrotic yndrome—podocyte ... damage from systemic ... Nephritic #Nephrotic #Syndromes
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
• Homogeneous: Systemic ... ) • Speckled: Systemic ... SLE), Sjogren's Syndrome ... Nucleolar: Diffuse systemic ... • Peripheral: Systemic