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diagnosis differential rheumatology lupus causes management clinical sle algorithm scale erythematosus systemic neurology dermatology pediatrics assessment peds physicalexam score signs
Cutaneous Lupus Erythematosus • Acute Cutaneous Lupus (ACLE) • Neutrophilic Dermatoses • Vascular Lesions •
Cutaneous Lupus (ACLE ... Cutaneous Lupus (SCLE ... Cutaneous Lupus (ICLE ... Cutaneous Lupus (CCLE
Subacute Cutaneous Lupus erythematosus (SCLE): Erythematous, warm, plaques in light exposed distribution (also on patient's neck),
erythematosus (SCLE ... Erythematosus (SCLE ... Erythematosus #SCLE
Lupus Classification Spontaneous Lupus - Cutaneous Lupus Erythematosus (CLE) - Systemic Lupus Erythematosus Drug-Induced Lupus - Drug-Induced
Erythematosus (CLE ... - Drug-Induced CLE ... (SCLE-DIL) -
Small Cell Lung Cancer (SCLC) Staging SCLC has 2 stages: 'Limited' or 'Extensive' Limited = disease fitting into
Cell Lung Cancer (SCLC ... ) Staging SCLC has ... #Lung #Cancer #SCLC
Causes of SVC Syndrome - Differential Diagnosis Framework • Benign (15-40%): Thrombosis (aka catheter-associated), Goiter, Fibrosing
Malignant (60-85%): SCLC
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - SLE ... pattern: - SjS, SLE ... Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... Speckled: - SLE
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Non-specific; common in SLE ... RA Anti-dsDNA - SLE ... - Drug-induced SLE ... syndrome Anti-Scl ... Diffuse) Anti-Sm - SLE
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Association with both SLE ... Associated with SCLE ... Anti-Ribo-P 5-15% If SLE ... higly specific for SLE
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... is rare in DIL, SCLE-DIL ... Erythematosus (SLE ... are evocative of SLE ... management of SLE
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus (SLE ... Anti-centromere, Scl
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