SJS antinuclear syndrome hematology anemia antibodies patterns anca differential testing

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12 results

Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
• Homogeneous pattern:
-

Antinuclear Antibody ... Testing - Nuclear ... #Testing #Nuclear ... #differential # ... diagnosis #rheumatology

ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

ANA Patterns and ... SLE), Sjogren's Syndrome ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Antinuclear Antibodies ... : The ANA patterns ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential

Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern:
• SLE, SSc, AIH, JIA
• dsDNA, chromatin,

Antinuclear Antibody ... Testing - Nuclear ... : • SjS, SLE, DM ... #Patterns #differential ... #diagnosis #rheumatology

Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA:
• PBC, SSc, PBC/SSc OS, PBC/SjS OS
• AMA
Speckled:
•

Antinuclear Antibody ... Testing Cytoplasmic ... Patterns Reticular ... #Patterns #differential ... #diagnosis #rheumatology

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

Vasculitides - Differential ... • Cogan Syndrome ... ) pattern: antibodies ... ) pattern: is usually ... #diagnosis #rheumatology

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

Antinuclear antibodies ... 30-40% Target: SS-A ... SLE-SSc-AlM overlap syndromes ... Lupusreference #Antinuclear ... erythematosus #diagnosis #rheumatology

Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
- Prior platelet count, family

Platelet Disorders - Differential ... smear, HIV/HCV testing ... function test, ANA ... anti-phospholipid antibodies ... changes), high MCV anemia

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cold Sensitive Antibodies ... Cold Agglutinin Syndrome ... Positive Coombs testing ... younger pts) Differential ... #hematology #diagnosis

Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of

Rheumatology Workup ... erythematosus (SLE) - Antinuclear ... double-stranded DNA antibodies ... the presence of anemia ... #Rheumatology

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