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differential management hematology sle vasculitis antibody antinuclear blood dermatology druginduced erythematosus nuclear patterns product reactions treatment apls bleeding bruising champs
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody Testing ... Scl70 (in some cases ... Antinuclear #Antibody #Testing ... #differential #diagnosis ... #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... RA, Sjogren's), antiphospholipid ... S - Systemic Lupus ... Ann Marie Kumfer ... CHAMPS #Mnemonic #diagnosis
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
everywhere) 2) A rash ... many differential diagnoses ... annular rash on ... #diagnosis #sle ... erythematosus #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar rash ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Discontinuation of causal ... Workup: - ANA ... comparison #table #rheumatology ... #diagnosis #management
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Diagnosis Algorithm ... Autoimmune Vasculitis (lupus ... for hepatitis B and ... #Algorithm #Causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... (C-ANCA): GPA > ... #differential #diagnosis ... #algorithm #rheumatology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid ... Hypercoagulable Workup Algorithm ... chromosomal causes ... : • Lupus Anticoagulant ... #diagnosis #hematology
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Papulosquamous Skin Rash ... - Differential Diagnosis ... Algorithm Erythrematous ... soles • Discoid Lupus ... #Algorithm #causes
Kawasaki Disease (KD) - Diagnosis and Management Summary Kawasaki Disease (KD) is the most common vasculitis of
Conjunctivitis, Mucositis, Rash ... , Cough • +/-Nausea ... Criteria - Fever lasting ... Polymorphous rash ... KD #vasculitis #rheumatology
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