11 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody Testing ... and Cytoplasmic Patterns ... Nuclear Patterns ... • Homogeneous pattern ... #differential #
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
- Nuclear Patterns ... Homogeneous pattern ... cases) Speckled pattern ... Ku Centromere pattern ... #differential #
Personality Disorders - Differential Diagnosis Algorithm
• Enduring pattern of experience and behaviour that deviates from cultural
• Enduring pattern ... control • The pattern ... situations • The pattern ... functioning • The pattern ... adolescence • The pattern
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
serial dilution, a pattern ... significant • Pattern ... : The ANA patterns ... not specific ANA Patterns ... Antibodies #ANA #patterns
Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA: 
 • PBC, SSc, PBC/SSc OS, PBC/SjS OS
 • AMA
Speckled:
 •
Antinuclear Antibody Testing ... Cytoplasmic Patterns ... #Cytoplasmic #Patterns ... #differential # ... diagnosis #rheumatology
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
: Subacute • Pattern ... : Subacute • Pattern ... or subacute • Pattern ... Insidious/slow • Pattern ... table
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... similar aggregation pattern ... agonists • This pattern ... considered first-line testing ... #hematology #hemepath
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential ... Diagnosis Algorithm ... involvement, irregular pattern ... pathophysiology #Hematology ... #algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Diagnosis Algorithm ... diverse genotypes): SS ... Consider RBC membrane disorder ... #workup #hematology ... #testing
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Pain - Arthritis Differential ... • Is there a pattern ... Mechanical/degenerative disorders ... an asymmetric pattern ... #Joint #pain #Differential