22 results
Diabetes Pathophysiology and Medication Targets

The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... hyperglycemia in type 2 diabetes ... commonly used diabetes ... /ambcarerx #Diabetes ... #Drug #Endocrinology
Drugs causing hyperkalemia
 • Impaired release of renin: NSAIDs, Beta blockers, Cyclosporine, tacrolimus, Diabetes, Elderly
 •
Drugs causing hyperkalemia ... Cyclosporine, tacrolimus, Diabetes ... Drospirenone #Drugs ... #hyperkalemia #medications ... #differential #diagnosis
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Euglycemic Diabetic ... Significant Adverse Drug ... level < 200 mg/dL Pathophysiology ... #Euglycemic #Diabetic ... Ketoacidosis #EuDKA #diagnosis
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
Hyperkalemia: Diagnostic ... renal failure • Drugs ... • Diabetic Nephropathy ... #Hyperkalemia #Diagnosis ... #algorithm #nephrology
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
Classification of Diabetes ... or neurogenic diabetes ... Idiopathic Nephrogenic diabetes ... or dipsogenic diabetes ... #Diabetes #Insipidus
Intrinsic Renal Disease - Differential Diagnosis
Vascular:
 • Macrovascular: Renal artery occlusion, Fibromuscular disease
 • Microvascular: TTP/HUS,
- Differential Diagnosis ... Membranous, FSGS, Diabetic ... Ischemia-induced: ATN • Drug ... Renal #Disease #nephrology ... #differential #diagnosis
Causes of Chronic Kidney Disease - Differential Diagnosis Algorithm
Decreased kidney function (eGFR < 60 ml/min/1.73 m2)
- Differential Diagnosis ... artery stenosis • Drugs ... Proteinuria) • Diabetes ... eosinophiluria) • Drugs ... KidneyDisease #Nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
- Differential Diagnosis ... syndrome • Drugs ... • HTN • Diabetes ... #Proteinuria #Nephrology ... #Differential #Diagnosis
Causes of Metabolic Acidosis with Elevated Anion Gap - Differential Diagnosis Algorithm
Elevated Anion Gap > 12
- Differential Diagnosis ... • Shock • Drugs ... errors Ketosis • Diabetic ... MetabolicAcidosis #AnionGap #Nephrology ... #Differential #Diagnosis
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
Correction of diabetic ... renal disease Drugs ... Hypomagnesemia #Causes #diagnosis ... #differential #medications ... #drugs #pharmacology