18 results
diagnosis differential neurology management erythematosus lupus sle symptoms systemic algorithm autoimmune hematology idiopathic inflammatory myopathies vasculitis antibodies arthritis cerebritis classification
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... TIF1y, NXP2, Mi-2, SAE ... Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... clinical #diagnosis #rheumatology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Necrotizing myopathy ... heliotrope rash, Shaw sign ... , holster sign, ... anti-synthetase syndrome ... #diagnosis #rheumatology
Idiopathic Inflammatory Myopathies - Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Immune-Mediated Necrotizing Myopathy ... Antisynthetase Syndrome ... Inclusion Body Myositis ... Myopathies #Idiopathic #Myopathy ... Managment #algorithm #Rheumatology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Normal CK - Myositis ... femoral heads • Myopathy ... Complications #pathophysiology ... #signs #symptoms
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
• Acute stroke syndromes ... Paraneoplastic syndrome ... Lack of UMN/LMN signs ... proximal weakness Myopathy ... mediated necrotizing myopathy
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
• Overlap Myositis ... Any inflammatory myopathy ... antisynthetase syndrome ... Inclusion body myositis ... IIMs #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Demyelinating syndromes ... Glomerulonephritis Myositis ... erythematosus #signs ... symptoms #diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Aseptic Meningitis, Myelopathy ... Disease, PRES Pathophysiology ... CNS #neurology #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... : • Pathophysiology ... diagnosis #management #hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis ... monophasic Pathophysiology ... of Transverse Myelitis ... the spinal cord (Myelopathy ... • Bilateral signs
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