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dermatology symptoms systemic algorithm erythematosus lupus sle management vasculitis autoimmune causes comparison myopathies myopathy syndrome antimda5 antimda5dm antinxp2 antinxp2dm arteritis
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Dermatomyositis ... can present with rash ... , Shaw sign, holster ... sign, and Gottron's ... #diagnosis #rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... Seborrhea • Dermatomyositis ... #rashes #differential ... #diagnosis #rheumatology
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Anti-Jo, +Anti-Mi2 Dermatomyositis ... muscle weakness, rash ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... #rheumatology # ... dermatology #diagnosis
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies Dermatomyositis ... heliotrope, shawl sign ... Inclusion Body Myositis ... Inflammatory #Myopathies #differential ... #rheumatology #
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
redness of the skin ... the Nikolsky sign ... the Nikolsky sign ... , the differential ... fever or Nikolsky sign
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
LcSSc) - distal skin ... thickening Signs ... acro-osteolysis, myositis ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
SLE) - Typical Signs ... Arthralgia / arthritis, Myositis ... Erythematosus #SLE #Signs ... #Symptoms #diagnosis ... #rheumatology
Combination of Skin Findings and Arthritis in Pediatrics Patient - Differential Diagnosis Malar rash: • A
Pediatrics Patient - Differential ... Diagnosis Malar ... migrans: • Target sign ... #differential # ... diagnosis #peds
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