49 results
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Multi-system autoimmune ... disease characterized ... thickening Signs ... Hepatic: PBC (primary ... Scleroderma #SSc #rheumatology
Pyoderma Gangrenosum: Autoimmune disorder resulting in a vasculitis which causes slowly progressive 
ulceration of the skin.
Pyoderma Gangrenosum: Autoimmune ... ulceration of the skin ... number of systemic diseases ... Goldberg, M.D. - UCSD ... #Gangrenosum #UCSDH
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
most frequent skin ... appearing during the disease ... polymorphism • Satellite ... Autoimmune manifestations ... oncology #clinical #skin
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
accompanies other autoimmune ... diseases • In ... with systemic diseases ... erythematosus (SLE) Signs ... Xeroderma (Dry skin
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Insufficiency Addison's Disease ... Common Causes: • Autoimmune ... Lymphoma Metastatic Disease ... pseudomonas) Autoimmune ... patches on the skin
Manifestations of IgG4-related disease by organ system.
 The most common primary disease features are indicated in
of IgG4-related disease ... The most common primary ... disease features ... Systems #Diagnosis #Hematology ... #Signs #Symptoms
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... common in SLE, autoimmune ... microsomal) - Autoimmune ... , Anti-gp210 - Primary ... diagnosis #table #rheumatology
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
anti-Sc170): Diffuse skin ... disease, Pulmonary ... disease (~93-95% ... Digital ulcers, Primary ... Autoantibodies #diagnosis #rheumatology
CLINICAL MANIFESTATIONS 
OF ADRENAL INSUFFICIENCY. 

Primary and secondary adrenal insufficiency:
 - Tiredness, weakness, mental depression
Primary and secondary ... - Vitiligo - Autoimmune ... thyroid disease ... disorders: - Pale skin ... Insufficiency #Signs
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary ... quadrant discomfort Signs ... of associated autoimmune ... disease (e.g. dryness ... disease, Persistent