23 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
(PBC), or with systemic ... rheumatoid arthritis (RA ... ) or systemic lupus ... Xeroderma (Dry skin ... #Diagnosis #Signs
Small Vessel Vasculitides
 • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
and C viruses. systemic ... lupus erythematosus ... , and Sjogren's ... syndrome • IgA ... in absence of skin
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
(15%) Skin (85% ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Seronegative Inflammatory Arthritis - Differential Diagnosis
 • Seronegative Rheumatoid Arthritis 
 • Infectious Arthritis: Viral, Bacterial,
Lupus Erythematous ... , Systemic Vasculitis ... , Sjogren's Disease ... Undifferentiated UCSD ... Differential #Diagnosis #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ... Anticoagulant (LAC) • Sjogren ... ribonucleoprotein) • RA ... • Scleroderma (Systemic ... Polymerase Ill • ANCA Vasculitis
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
central nervous system ... disease - systemic ... lupus erythematosus ... disease - Sjögren ... Vessels #Diagnosis #Rheumatology
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
PSS: Sjogren syndrome ... RA: rheumatoid arthritis ... SLE : systemic ... lupus. ... Table #Pulmonary #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... - Purpura - Skin ... - 10% SLE or RA ... lupus erythematosus ... classification #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
HUS, autoimmune (RA ... , Sjogren's), antiphospholipid ... syndrome, atheroembolic ... glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Associated with skin ... heart block • Sjogren ... #Lupus #Erythematosus ... Summary #diagnosis #rheumatology