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diagnosis differential classification erythematosus hematology joint oncology pain sle symptoms associations autoantibodies champs complement conditions cryoglobulinemia cryoglobulins extrarticular hypocomplementemia low
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’ ... rheumatoid arthritis (RA ... ) or systemic lupus ... Xeroderma (Dry skin ... #Diagnosis #Signs
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(15%) Skin (85% ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ... Anticoagulant (LAC) • Sjogren ... ribonucleoprotein) • RA ... • Scleroderma (Systemic ... Polymerase Ill • ANCA Vasculitis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
HUS, autoimmune (RA ... , Sjogren's), antiphospholipid ... syndrome, atheroembolic ... Lupus Erythematosus ... #differential #hematology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
gangrenosum • IBD • RA ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... differential #diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... - Purpura - Skin ... - 10% SLE or RA ... lupus erythematosus ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... • Cogan Syndrome ... lupus erythematosus ... purpura: strong sign ... differential #diagnosis #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Neurologic system ... Lyme disease, Vasculitis ... enlargement - Sjögren's ... Scleroderma Thickened skin ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA ... ) • Cutaneous vasculitis ... Vasculitis: • ... #Syndrome #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... dermatomyositis, Sjogren ... Non-autoimmune rheumatologic ... Seizures • Strokes Skin
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