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diagnosis symptoms associations erythematosus lupus sle systemic table antibodies arthritis behcet classification conditions cryoglobulinemia cryoglobulins differential disease diseases extrarticular joint
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... Rheumatoid factor - RA ... Anti-SSB (La) - Sjogren's ... #Autoantibodies ... diagnosis #table #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... Rheumatology • ... Anticoagulant (LAC) • Sjogren ... ribonucleoprotein) • RA ... Polymerase Ill • ANCA Vasculitis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... - 10% SLE or RA ... - 5 to 20% Sjögren's ... reticularis & skin ... classification #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(15%) Skin (85% ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
• Scleritis - RA ... Lyme disease, Vasculitis ... enlargement - Sjögren's ... Scleroderma Thickened skin ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA ... ) • Cutaneous vasculitis ... #Syndrome #Rheumatology ... #Diagnosis #Management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... response to local skin ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Rheumatoid Arthritis - Signs and Symptoms • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans • Pulmonary:
Complications of DMARDs • Skin ... Vascular: Rheumatoid vasculitis ... Thrombocytosis, Felty's syndrome ... Rheumatoid #Arthritis #RA ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... • Anti-Ro/SSA autoantibodies ... dermatomyositis, Sjogren ... Non-autoimmune rheumatologic ... Seizures • Strokes Skin
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
• Inner ear • Skin ... as: • SLE • RA ... Most common • Sjogren ... Polychondritis #rheumatology ... #diagnosis #management
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