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Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... likely: • Smear: schistocytes ... Differential #Diagnosis #Management
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Differential → schizocytes ... Anemia #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Peripheral smear: Schistocytes ... studies - PBS: + Schistocytes ... causes #treatment #management
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
Schistocytes - The ... arrows point to schistocytes ... Also called schizocytes ... Schistocytes are ... Schistocytes are
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis of schistocytes ... BCM_InternalMed #schistocytes
Schistocytes can assume a shape resembling natural or man-made objects such as arrowheads, fish, collar buttons,
Schistocytes can ... #HelmetCells #Schistocytes
Causes of AKI in Pregnancy - Differential Diagnosis Creatinine - Platelets - Transaminases - LDH - PT/PTT
LDH - PT/PTT - Schistocytes
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Megaloblastic Anemia Schistocytes
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases Acanthocyte (spur cell), Basophilic stippling, Bite cell,
sideroblast, Schistocyte
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
transfusions) • Schistocytes
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