354 results
ILD of Known Cause - Differential Diagnosis
Exposure:
 • Occupational: Asbestosis, Silicosis, Hypersensitivity, Pneumonitis
 • Treatment Related:
ILD of Known Cause ... Tissue Disease: RA, Scleroderma ... BrighamChiefs #ILD
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
SLE), Sjogren's Syndrome ... Systemic sclerosis or scleroderma ... systemic sclerosis/scleroderma ... systemic sclerosis/scleroderma ... Systemic sclerosis/scleroderma
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Systemic Sclerosis (Scleroderma ... 3 Subtypes of Scleroderma ... Sclerosis sine scleroderma ... • Pulmonary: ILD ... HTN) • Renal: scleroderma
Interstitial Lung Diseases (ILD)
Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): 
 • Hypersensitivity pneumonitis, Farmer's lung, Bird
Lung Diseases (ILD ... Exposure-Related ILD ... ILD caused by inhalation ... Methotrexate ILD ... Churg Strauss syndrome
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Telangiectasia • Scleroderma ... Thickened skin • Scleroderma ... gangrenosum • IBD ... Antiphospholipid-antibody syndrome
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal Syndromes ... Antiphospholipid Syndrome ... Complement Levels: Scleroderma ... differentiation syndrome ... Pulmonary #Renal #Syndromes
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Antiphospholipid Antibody Syndrome ... LAC) • Sjogren Syndrome ... TIF1y, MDA5 • Scleroderma ... RNA Polymerase Ill
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
• Clubbing - IBD ... GI - Felty syndrome ... Spondyloarthropathy-IBD ... Telangiectasia • Scleroderma ... Thickened skin • Scleroderma
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
SLE), Sjogren's Syndrome ... systemic sclerosis/scleroderma ... systemic sclerosis/scleroderma ... Systemic sclerosis/scleroderma ... Arthritis, Sjögren Syndrome
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
hemolytic-uremic syndrome ... hypertension • Scleroderma ... anemia" • HELLP syndrome