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diagnosis management reactions blood hemeonc product treatment coagulation comparison dic disseminated ebm hemophagocytic heparin hit hlh induced intravascular leukostasis lymphohistiocytosis
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
Major Clinical Trials ... Thresholds in Critical ... unnecessary and cause ... Transfusions are ... #Thresholds #Hematology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Risk factors: Critical ... blood donor • Pathophysiology ... without other cause ... • Pathophysiology ... #Reactions #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... more likely to cause ... RBCs (stored at ... diagnosis #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... more likely to cause ... RBCs (stored at ... diagnosis #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
incompatible blood transfusion ... protein C and S Pathophysiology ... organ damage Clinical ... Treat primary cause ... treatment #management #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... Diuretics, PRBC transfusion ... Lysis Syndrome: • Pathophysiology ... diagnosis #management #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
♀, ↑Age, ESRD Pathophysiology ... Diagnosis: • Clinical ... → Calculate 4T score ... • If 4T score ... Management #Treatment #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Clinical Presentation ... Pathophysiology ... molecular diagnosis: HScore ... Diagnosis #Management #Hematology
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