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management rheumatology syndrome differential hepatology hlh lupus lymphohistiocytosis neurology sle b12 cerebritis cirrhosis cns coagulation cobalamin comparison deficiency dic disseminated
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... (HLH) Pathophysiology ... • Autoimmune diseases ... Drugs, Unknown cause ... Treatment: •
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
initiation of nutrition ... due to chronic disease ... hyperparathyroidism Treatment ... #Differential #Diagnosis ... #Pathophysiology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... , PRES Pathophysiology ... autoantibodies that will cause ... permeability Diagnosis ... #cerebritis #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... • Severe Liver Disease ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
advanced liver disease ... • Caused by splanchnic ... Pathophysiology: ... Exclude other AKI causes ... Treatment Overview
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
is rare in DIL, SCLE-DIL ... constitutional symptoms • Treatment ... life-threatening • Treatment ... Evolution: Chronic disease ... #diagnosis #management
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... to IBD, celiac disease ... large total body stores ... Check for IF ab Treatment ... #management #nutrition
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... bouts of HTN Diagnostic ... MCTD - Bechet disease ... antibodies • Nutritional ... Transverse Myelitis Treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... ▪ Autoimmune diseases ... Pathophysiology ... : HScore a. ... #Management #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... Myeloproliferative Disease ... Platelet Disorders • Nutritional ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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