31 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
thrombocytopenic purpura ... /hemolytic uremic ... syndrome. ... thrombocytopenia, Hematology ... #Diagnosis #Differential
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... syndrome (ST-HUS ... anemia" • HELLP syndrome ... #schistocytes #differential ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... thrombocytopenic purpura ... uremic syndrome ... Extravascular #Causes #differential ... #diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Diagnosis Secondary ... iron deficiency, hemolysis ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology ... #secondary
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Volume (MCV) - Differential ... Hypersplenism • Secondary ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... → Refer to hematology ... blood loss, Acute hemolysis ... Kawasaki, Nephrotic syndrome ... Diagnosis #Algorithm #hematology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Leukocytoclastic Vasculitis Secondary ... Petechiae, Palpable purpura ... Disease • Cogan syndrome ... Vasculitis #skin #dermatology ... #rheumatology #
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Petechiae/Purpura ... Pathophysiology: ... of primary or secondary ... #Diagnosis #Dermatology ... Palpable #Algorithm #Differential
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... HUGE treatment implications ... thrombocytopenic #purpura ... Diagnosis #Table #Hematology