14 results
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... Hyperkalemia ... • Increased EC shift ... pathophysiology #pharmacology ... #medications #druginduced
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
phlebotomy High ... reactions Common Drugs ... Intracellular Shift ... lysis syndrome - Rhabdomyolysis ... differential #diagnosis #causes
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
Drugs associated ... with hypokalemia ... - Shift from extracellular ... - Insulin (high ... diagnosis #nephrology #Causes
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
phlebotomy High ... reactions Common Drugs ... Intracellular Shift ... lysis syndrome - Rhabdomyolysis ... differential #diagnosis #causes
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Management Summary Causes ... - Toxins - Drugs ... Shift of extracellular ... per day until stable ... Diagnosis #Management #causes
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Drugs (Statins), ... Shift of extracellular ... per day until stable ... Dialysis for severe hyperkalemia ... Management #Summary #causes
Causes of Hyperkalemia
Pseudohyperkalemia
 - Tourniquet use
 - Hemolysis (in vitro)
 - Leukocytosis
 - Thrombocytosis
Intra- to extracellular
Causes of Hyperkalemia ... extracellular potassium shift ... chemotherapy - Rhabdomyolysis ... anti-inflammatory drugs ... #Causes #diagnosis
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
constipation, diarrhea, nausea ... ); nausea, vomiting ... patients sensitive to high ... #medications #pharmacology ... #table #comparison
Rhabdomyolysis - Differential Diagnosis Framework
Rhabdomyolysis = Destruction of skeletal muscle with leakage of contents into circulation.
Rhabdomyolysis - ... Electrolytes: Hypokalemia ... Lipid-lowering drugs ... Differential #Diagnosis #Causes ... #nephrology #table
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
Causes of Hyperkalemia ... extracellular shift ... Drug-associated: ... Differential #Diagnosis #High ... Classification #Causes