30 results
A schema of the pathophysiology of the inborn errors of metabolism, excluding complex storage diseases. Helps
schema of the pathophysiology ... MetabolicEmergency #Genetics ... #Pathophysiology ... Diagnosis #Algorithm #Differential ... #Neonatology #Peds
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
Curve Left Shift ... - Sickle cell anemia ... Dissociation #Curve #Pathophysiology ... #Left #Right #Shift ... #Differential #
Lab patterns seen in Inborn Errors of Metabolism

A table of lab values compiled from UpToDate and
metabolicemergency-pathophysiology-differential-pediatrics-metabolism-algorithm-diagnosis ... #Neonatology #Peds ... #Table #NICU #Genetics
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Band neutrophils are ... Left Shift: • ... Metamyelocyte (Left Shift ... #differential # ... #pathophysiology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Increased EC shift ... #hyperkalemia #differential ... #diagnosis #pathophysiology
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
not proven) - Genetic ... expression - Age ... - Normocytic Anemia ... Temporal #Arteritis #Pathophysiology
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Pathophysiology: ... 1) If lesions are ... manifestations are ... #Diagnosis #Dermatology ... Palpable #Algorithm #Differential
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Bimodal Age ... Most common, Wide age ... Classification #pathophysiology ... #Hematology #Diagnosis ... #NonHodgkin #differential
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
Electrolyte/fluid shifts ... • These shifts ... • Arrhythmias are ... Syndrome #Nutrition #Differential ... #Diagnosis #Pathophysiology
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
liver disease) are ... common, there are ... Reye syndrome (Peds ... deficiency #Ammonia #Pathophysiology ... Hyperammonemia #Differential