13 results
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Causes of Prolonged ... INR), Prolonged PTT ... Differential #Diagnosis #Algorithm ... #Causes #Hematology ... #coagulation #disorders
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Severe Liver ... Treat primary cause ... INR < 2.3 - APTT ... #diagnosis #causes ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... (DIC) c. ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
the PT and the aPTT ... • Reduced liver ... intravascularcoagulation (DIC ... #differential #hematology ... #coagulation
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
marrow disease - DIC ... Defects: • DIC ... deficiency • Liver ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Iatrogenic) • Liver ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
presents with coagulation ... schistocytes, DIC ... child * Severe cases ... pregnancy * Severe coagulation ... Obstetrics #OBGyn #Hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
presents with coagulation ... schistocytes, DIC ... child * Severe cases ... pregnancy * Severe coagulation ... AFLP #obstetrics #hematology
Causes of Altered Level of Consciousness GCS < 7 - Differential Diagnosis Algorithm

Brain Involvement - Hemispheric
Causes of Altered ... Abscess • Skull fracture ... Vasculitis • TTP • DIC ... - Excesses • Liver ... Hypernatremia • Hypercalcemia
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... Warfarin • Acute DIC ... discern these causes ... disease • Acute DIC ... Differential #Diagnosis #Hematology