34 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... • Hyperkalemia ... #TLS #Pathophysiology
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
of Tumor Lysis Syndrome ... Calcium ≤ 7.0 mg/dL Clinical ... : • Hypovolemia ... hydroxide • Hyperkalemia ... #TumorLysis #Syndrome
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... Transcellular Shift ... - Refeeding Syndrome ... #Hypokalemia ... potassium #low #pathophysiology
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... hyperuricemia, #hyperkalemia ... hyperphosphatemia, #hypocalcemia ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... creatinine) • Cell shift ... : Hypokalemic periodic ... mmol creatinine) High ... #hypokalemia
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC ... shift of K (Succinylcholine ... MunerMohamed1 #hyperkalemia ... differential #diagnosis #pathophysiology
Emergency Management of Hyperkalemia in Adults
Assess Patient - Airway Breathing Circulation Disability Exposure (ABCDE) Approach
 •
Management of Hyperkalemia ... Treatment guided by clinical ... scenario, ECG and ... Gluconate IV Shift ... recurrence #Hyperkalemia
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... 6L/day) • For hyperkalemia ... with Ca only if EKG ... otherwise treat with "hyperkalemia ... #TLS #oncology
BRASH Syndrome

B - Bradycardia
R - Renal failure
A - AV nodal blockade
S - Shock
H - Hyperkalemia

Typical ECG
S - Shock H - Hyperkalemia ... Typical ECG ... other findings of hyperkalemia ... Aggressive treatment of hyperkalemia ... diagnosis #management #pathophysiology
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
associated with hypokalemia ... hypomagnesemia Hypokalemia ... - Shift from extracellular ... - Insulin (high ... panitumumab) #Drugs #hypokalemia