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Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Benyzlpenicillin, blood ... #differential #diagnosis ... #pathophysiology ... #pharmacology #potassium ... #medications #druginduced
Causes of Hyperkalemia Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
caused by excess potassium ... transcellular shifts ... renal function, medication ... is rarely the sole ... dysfunction is common #Diagnosis
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 Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... insufficiency/Failure • SLE ... Medications 2.
Hyperkalemia Differential Diagnosis Algorithm R/O Pseudo-hyperkalemia: • Possible Lab error! Alwavs Repeat Blood sample! • Leukocytosis, Thrombocytosis:
Diagnosis Algorithm ... Alwavs Repeat Blood ... while drawing blood ... Algorithm #causes #potassium ... #high #pathophysiology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... insufficiency/Failure • SLE ... Medications 2.
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... and ECG changes ... blocks, QRS axis shift ... #potassium #high ... #diagnosis #management
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
Framework • Cellular Shift ... hyperosmolality - Medications ... : Blood draw error ... #Causes #potassium ... #high
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
patients with hypokalemia ... creatinine) • Cell shift ... effective arterial blood ... #urine #potassium ... differential #algorithm #diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Disease, PRES Pathophysiology ... thrombosis and/or blood-brain ... Lumbar Puncture, EEG ... Induction Rx: high-dose
Pseudohyperkalemia vs Reverse Hyperkalemia Pseudohyperkalemia and reverse pseudohyperkalemia are both conditions where potassium levels appear falsely elevated. Pseudohyperkalemia: This
leukocytes, or red blood ... • Occurs after blood ... • ECG findings ... no changes in ECG ... #Diagnosis
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