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diagnosis differential management causes nephrology pharmacology treatment blood cardiology classification druginduced k leukostasis lysis product reactions syndrome tls transfusions tumor
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
and Pathophysiology ... - Hyperkalemia ( ... high potassium levels ... , in states of hypokalemia ... (or low potassium
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC ... shift of K (Succinylcholine ... differential #diagnosis #pathophysiology ... #pharmacology #potassium ... #medications #druginduced
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... : • Digoxin ... Intracellular Shift ... Medications 2. ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... : • Digoxin ... Intracellular Shift ... Medications 2. ... #high #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Etiology: • Medications ... Calcineurin inhibitors, Digoxin ... heparinized tube) • ECG ... acidosis) • Low ... Management #Treatment #potassium
Hyperkalemia Management Pseudohyperkalemia: 1. Hemolyzed sample 2. Blood drawn from a site/line where potassium or TPN is
Hyperkalemia Management ... site/line where potassium ... minutes-hour) -Shift ... or dialysis • SLOW ... #high
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... , Elevated Cr, Low ... hydration - Hyperkalemia ... unless worrisome EKG ... diagnosis #management #hematology
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
extracellular shift ... Digoxin and related ... Drug-associated: heparin, low-molecular-weight ... Differential #Diagnosis #High ... #Potassium #Classification
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
High mortality. ... Hypocalcemia, Hyperkalemia ... products contain potassium ... Hypothermia: Due to low ... diagnosis #management #hematology
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