13 results
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Kidney Injury (AKI ... Cancer Related • Hypercalcemia ... change disease • Hematologic ... #Cancer #Oncology ... Classification #Nephrology
Simplified Approach to Acute Kidney Injury (AKI)
1) IS THIS AN EMERGENCY? 
Is there a dialysis indication
Kidney Injury (AKI ... AEIOU ) or anuria ... require urgent nephrology ... CONSIDER INTRINSIC CAUSES ... workup #diagnosis #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Management Summary Causes ... declines > ALT) • AKI ... + myoglobin AKI ... Shift of extracellular ... #treatment #nephrology
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Causes of Fatigue ... Liver Failure • Hypercalcemia ... Neoplastic / Hematologic ... • Anemia • ... • Drug Abuse (e.g
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Gammopathies C - HyperCalcemia ... 40 ml/min A - Anemia ... Causes of false- ... MGUS #diagnosis #hematology ... #oncology
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm
Transcellular Shift - Appropriate renal excretion (GFR,
Causes of Hyperkalemia ... Intercellular Shift ... Transcellular Shift ... • Cell Lysis (e.g ... IntercellularShift #Nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... Transcellular Shifts ... megaloblastic anemia ... #Causes #differential ... #diagnosis #nephrology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... fever - ACS, AKI ... hydration - Hyperkalemia ... unless worrisome EKG ... diagnosis #management #hematology
Causes of Hyperkalemia - Reduced Excretion - Differential Diagnosis Algorithm

Reduced flow through distal nephron - TTKG
Causes of Hyperkalemia ... • Low EABV (e.g ... renal failure • AKI ... • NSAlDs #Hyperkalemia ... IntercellularShift #Nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Weakness, cramping, nausea ... , RTA Type IV, AI ... only if no clear cause ... Terbutaline 7 µg/kg ... Treatment #potassium #nephrology