17 results
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
edgarvlermamd #Potassium ... #Binding #KBinders ... #Kayexelate #Comparison ... #Table #Pharmacology ... #Patiromer #HyperKalemia
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... Management of Hyperkalemia ... #Hyperkalemia # ... treatment #pharmacology ... #table #comparison
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat Hyperkalemia ... #Binding #Hyperkalemia ... #medications #pharmacology ... #table #comparison
Characteristics of Commonly Used Phosphate Binders 
Aluminum 
 - Potent and effective 
 - Useful for
Lower risk of hypercalcemia ... range - Lack of hypercalcemia ... requirements - Lack of hypercalcemia ... range - Lack of hypercalcemia ... #Table #Comparison
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... intracellular calcium causes ... - Hyperkalemia ( ... binds to the same ... (or low potassium
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... Suspicion for Hyperkalemia ... Drugs Causing Hyperkalemia ... Metabolic acidosis - Hyperkalemia ... cantaloupe #hyperkalemia
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... Suspicion for Hyperkalemia ... Drugs Causing Hyperkalemia ... Metabolic acidosis - Hyperkalemia ... images/12834 #hyperkalemia
Considerations for Crystalloids - 0.9% NS vs LR vs Plasma-Lyte
 - Causes hyperkalemia?
 - Safe to
hyperkalemia? ... patients with hyperkalemia ... Update: AKI in NS row ... #Crystalloids #pharmacology ... #indications #comparison
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
• LDH ↑ • Hyperkalemia ... /Late - Hypercalcemia ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm
Transcellular Shift - Appropriate renal excretion (GFR,
Causes of Hyperkalemia ... Intercellular Shift ... , TTKG, distal flow ... -1 agonism • Digoxin ... #Hyperkalemia